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Coronavirus subvariant JN.1 co-infection with influenza and Pneumococcal causes severe illness

The COVID-19 subvariant JN.1 is dominant in the U.S and is increasing the number of cases and deaths in many countries around the world. Experts warn that the JN1 variant is dangerous because of its rapid spread, especially being susceptible to co-infection with diseases such as influenza, pneumococcal pneumonia causes pulmonary embolism, progressive respiratory failure… Increased risk of death several times with very high treatment costs.

During the interseasonal period, many viruses and bacteria circulate and thrive, causing millions of burdens on diseases and the national health system. Among them, most notably COVID-19 with sub-variants of SARS-CoV-2, possessing new antigenic characteristics and it is expected to have the potential to spread strongly in the community, potentially the risk of reoutbreak of the disease in the near future. Meanwhile, respiratory infections caused by influenza A, B and pneumococcus in the country are complicated, the number of cases, severe course, complications and hospitalizations for persistently elevated treatment. This has many potential risks of COVID-19 coinfection with influenza, pneumococcus causing severe disease, threatening people’s health and lives during the upcoming holiday season.

What is JN.1 the latest COVID-19 variant?

Subvariants of SARS-CoV-2 are virus strains that are recombinant from the original virus through a process of nature changes in their genome. In particular, SARS-CoV-2 has a high tendency to recombinant, frequent changes in genome structure, spike protein mutations from the original virus and forming many new variants, these variants continue to mutate into many other sub-variants in huge numbers. For this reason, SARS-CoV-2 is continuously enhanced with the ability to “dodge” immunity, easily penetrate, and harm the body, increased level of attack and damage to organs.

SARS-CoV-2 primarily and rapidly affects the upper respiratory tract (nose, sinuses, and throat), and lower respiratory tract (lungs and trachea) causes loss of smell, taste, fatigue, fever, shortness of breath, cough,.. In particular, new sub-variants of SARS-CoV-2 are capable of becoming more and more powerful, infecting deep in the lungs, even binds to the cell membrane of a sick person, causing more damage to the lungs, densely infected lungs and leading to death. Scientists are concerned that it is so mutated that it will completely escape the protection of vaccines and antibodies against Covid-19, will probably cause another wave of illness like the original Omicron variant did in 2021.

The opinions of expertsy

Dr. T. Ryan Gregory, an evolutionary biologist at the University of Guelph in Ontario, said: “It’s clear that it’s highly competitive with existing XBB variants, and it looks like it’s on track to become the next type of globally dominant variant.” who are tracking the evolution of the virus that causes Covid-19.

The good news is that a recent study from Dr. David Ho’s lab at Columbia University found that current Covid-19 vaccines, designed to enhance the body’s resistance to the XBB variant strain, which also provides good protection against BA. 2.86 and its tributaries, including JN.1.

According to the summary results of the report from the Chinese Center for Disease Control and Prevention (China CDC), about 81% of Covid-19 cases have mild pneumonia, 14% severe pneumonia such as lack of oxygen, shortness of breath and 5% of critical pneumonia causes respiratory failure, shock, multi-organ malformations and can be fatal.

In addition, many studies conducted on the brains of people who died from Covid-19 show that the virus can enter the bloodstream, evade the blood-brain barrier to penetrate and cause damage to the central nervous system. It is associated with severe symptoms of disease in the nervous system. Some other complications that Covid-19 can cause include: acute myocardial injury, cardiovascular complications, thrombosis, venous thromboembolism, pulmonary embolism, ischemic events, vasoconstrictor reactions and olfactory damage,…

Although, on May 5, 2023, the World Health Organization (WHO) declared Covid-19 no longer a public health emergency, causing global concern but does not mean that Covid-19 is less dangerous, becoming even more dangerous with the constant emergence of many new subvariants. Variants are listed by the WHO in three distinct categories: variants of concern, which are the highest, variations of interest and variants are being monitored. The JN.1 now joins other sub-variants of Omicron such as XBB.1.5, XBB.1.16, EG.5 and BA.2.86 in the list of variants of concern.

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